IDSwiss AccGene NameAliasDescription
9966O95150TNFSF15TL1; TL1A; VEGI; MGC129934; MGC129935tumor necrosis factor (ligand) superfamily, member 15
[more aliases]
FunctionThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.


Gene OntologyGO:0005164 tumor necrosis factor receptor binding
GO:0005887 integral to plasma membrane
GO:0006919 caspase activation
GO:0005886 plasma membrane
GO:0001937 negative regulation of endothelial cell proliferation
GO:0000074 regulation of progression through cell cycle
GO:0005625 soluble fraction
GO:0007250 activation of NF-kappaB-inducing kinase
GO:0016020 membrane
GO:0005102 receptor binding
GO:0006955 immune response
GO:0042107 cytokine metabolism
GO:0005615 extracellular space
GO:0007165 signal transduction

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TNFRSF6Bin vivo
TNFRSF25in vivo

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

© 2008 National Taiwan Univerisity, Taipei, Taiwan