IDSwiss AccGene NameAliasDescription
970P32970TNFSF7CD70; CD27L; CD27LGtumor necrosis factor (ligand) superfamily, member 7
[more aliases]
FunctionThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.


Gene OntologyGO:0008283 cell proliferation
GO:0005164 tumor necrosis factor receptor binding
GO:0007267 cell-cell signaling
GO:0006915 apoptosis
GO:0005887 integral to plasma membrane
GO:0016020 membrane
GO:0005102 receptor binding
GO:0005615 extracellular space
GO:0006955 immune response
GO:0007165 signal transduction

Database cross references


Integrated protein interaction and pathway information

Pathway (NetPath)PubMedRegulationExperiment
IL-212459040 DownregulationMicroarray
TNF-alpha12212969,14641910 UpregulationMicroarray,Non-Microarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

© 2008 National Taiwan Univerisity, Taipei, Taiwan