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ID | Swiss Acc | Gene Name | Alias | Description | 970 | P32970 | TNFSF7 | CD70; CD27L; CD27LG | tumor necrosis factor (ligand) superfamily, member 7 |
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[more aliases] |
Function | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. |
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Associations | TCM-Gene | TCM-Gene-Disease |
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Gene Ontology | GO:0008283 cell proliferation GO:0005164 tumor necrosis factor receptor binding GO:0007267 cell-cell signaling GO:0006915 apoptosis GO:0005887 integral to plasma membrane GO:0016020 membrane GO:0005102 receptor binding GO:0005615 extracellular space GO:0006955 immune response GO:0007165 signal transduction |
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Database cross references
STITCH | TNFSF7 |
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Integrated protein interaction and pathway information
Pathway (NetPath) | PubMed | Regulation | Experiment |
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IL-2 | 12459040 | Downregulation | Microarray |
TNF-alpha | 12212969,14641910 | Upregulation | Microarray,Non-Microarray |
Pathway (KEGG) | [Cytokine-cytokine receptor interaction] |
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