IDSwiss AccGene NameAliasDescription
944P32971TNFSF8CD153; CD30L; CD30LGtumor necrosis factor (ligand) superfamily, member 8
[more aliases]
FunctionThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin\'s and some non-Hodgkin\'s lymphomas.


Gene OntologyGO:0008283 cell proliferation
GO:0005164 tumor necrosis factor receptor binding
GO:0007267 cell-cell signaling
GO:0005887 integral to plasma membrane
GO:0016020 membrane
GO:0005102 receptor binding
GO:0006955 immune response
GO:0007165 signal transduction
GO:0006917 induction of apoptosis
GO:0005615 extracellular space

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
ANGin vitro
TNFRSF8in vitro

Pathway (NetPath)PubMedRegulationExperiment
IL-715905508 UpregulationNon-Microarray
TNF-alpha12754109 UpregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

© 2008 National Taiwan Univerisity, Taipei, Taiwan