IDSwiss AccGene NameAliasDescription
943P28908TNFRSF8CD30; KI-1; D1S166Etumor necrosis factor receptor superfamily, member 8
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.


Gene OntologyGO:0005515 protein binding
GO:0008285 negative regulation of cell proliferation
GO:0004888 transmembrane receptor activity
GO:0016020 membrane
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0007165 signal transduction

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TNFRSF8in vivo
TRAF1in vivo
TRAF2in vitro;in vivo;yeast 2-hybrid
TRAF3in vivo
TRAF5in vitro;in vivo;yeast 2-hybrid
TNFSF8in vitro
TTRAPin vivo;yeast 2-hybrid
ALKin vitro;in vivo

Interacting Partners (NetPath)TRAF2 [10860854 ]

Interacting Partner (IntAct)Interaction typeDetection method
BCL6 physical interaction anti bait coip

Pathway (NetPath)PubMedRegulationExperiment
B Cell Receptor11898398 UpregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

© 2008 National Taiwan Univerisity, Taipei, Taiwan