IDSwiss AccGene NameAliasDescription
939P26842TNFRSF7T14; CD27; S152; Tp55; MGC20393tumor necrosis factor receptor superfamily, member 7
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.


Gene OntologyGO:0007166 cell surface receptor linked signal transduction
GO:0006915 apoptosis
GO:0005887 integral to plasma membrane
GO:0046330 positive regulation of JNK cascade
GO:0007001 chromosome organization and biogenesis (sensu Eukaryota)
GO:0003677 DNA binding
GO:0016064 humoral defense mechanism (sensu Vertebrata)
GO:0004888 transmembrane receptor activity
GO:0016020 membrane
GO:0007283 spermatogenesis
GO:0006955 immune response
GO:0000786 nucleosome
GO:0008588 release of cytoplasmic sequestered NF-kappaB
GO:0005515 protein binding
GO:0005634 nucleus
GO:0042100 B cell proliferation
GO:0045078 positive regulation of interferon-gamma biosynthesis
GO:0045579 positive regulation of B cell differentiation
GO:0048305 immunoglobulin secretion
GO:0045582 positive regulation of T cell differentiation
GO:0043027 caspase inhibitor activity
GO:0005576 extracellular region
GO:0006916 anti-apoptosis
GO:0006917 induction of apoptosis

Database cross references


Integrated protein interaction and pathway information

Interacting Partner (IntAct)Interaction typeDetection method
SIVA physical interaction two hybrid, anti bait coip
TRAF2 physical interaction two hybrid

Pathway (NetPath)PubMedRegulationExperiment
B Cell Receptor9712721 DownregulationMicroarray
IL-212459040,12435740 DownregulationMicroarray
IL-416220538 DownregulationMicroarray
TGF-beta Receptor15592526 UpregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

© 2008 National Taiwan Univerisity, Taipei, Taiwan