IDSwiss AccGene NameAliasDescription
8995Q9UNG2TNFSF18TL6; AITRL; GITRL; hGITRLtumor necrosis factor (ligand) superfamily, member 18
[more aliases]
FunctionThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.


Gene OntologyGO:0007267 cell-cell signaling
GO:0005164 tumor necrosis factor receptor binding
GO:0016021 integral to membrane
GO:0016020 membrane
GO:0005102 receptor binding
GO:0006916 anti-apoptosis
GO:0005615 extracellular space
GO:0007165 signal transduction
GO:0006955 immune response

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TNFRSF18in vivo

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

© 2008 National Taiwan Univerisity, Taipei, Taiwan