IDSwiss AccGene NameAliasDescription
8797O00220TNFRSF10ADR4; APO2; MGC9365; TRAILR1; TRAIL-R1; TRAILR-1tumor necrosis factor receptor superfamily, member 10a
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.


Gene OntologyGO:0006915 apoptosis
GO:0005035 death receptor activity
GO:0016021 integral to membrane
GO:0006919 caspase activation
GO:0004872 receptor activity
GO:0045569 TRAIL binding
GO:0008656 caspase activator activity
GO:0007250 activation of NF-kappaB-inducing kinase
GO:0016020 membrane
GO:0008625 induction of apoptosis via death domain receptors
GO:0006917 induction of apoptosis
GO:0007165 signal transduction

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
COL2A1in vivo
CASP8in vivo
TRADDin vivo
BCL10in vivo
TNFSF10in vitro;in vivo
DAP3in vivo;yeast 2-hybrid
RIPK1in vivo
MOAP1in vivo
RASSF1in vivo
MADDin vitro;in vivo
TNFRSF10Ain vitro;in vivo
TNFRSF10Bin vitro
TNFRSF10Din vitro;in vivo
BTKin vivo
CD4in vivo
FADDin vivo

Interacting Partner (IntAct)Interaction typeDetection method
TNFSF10 physical interaction pull down

Pathway (NetPath)PubMedRegulationExperiment
TGF-beta Receptor15592526 DownregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction] [Apoptosis] [Natural killer cell mediated cytotoxicity]

Pathway (CGAP/BioCarta)[Induction of apoptosis through DR3 and DR4/5 Death Receptors ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan