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ID | Swiss Acc | Gene Name | Alias | Description | 8797 | O00220 | TNFRSF10A | DR4; APO2; MGC9365; TRAILR1; TRAIL-R1; TRAILR-1 | tumor necrosis factor receptor superfamily, member 10a |
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[more aliases] |
Function | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. |
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Associations | TCM-Gene | TCM-Gene-Disease |
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Gene Ontology | GO:0006915 apoptosis GO:0005035 death receptor activity GO:0016021 integral to membrane GO:0006919 caspase activation GO:0004872 receptor activity GO:0045569 TRAIL binding GO:0008656 caspase activator activity GO:0007250 activation of NF-kappaB-inducing kinase GO:0016020 membrane GO:0008625 induction of apoptosis via death domain receptors GO:0006917 induction of apoptosis GO:0007165 signal transduction |
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Database cross references
STITCH | TNFRSF10A |
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Integrated protein interaction and pathway information
Interacting Partner (IntAct) | Interaction type | Detection method |
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TNFSF10 | physical interaction | pull down |
Pathway (NetPath) | PubMed | Regulation | Experiment |
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TGF-beta Receptor | 15592526 | Downregulation | Microarray |
Pathway (KEGG) | [Cytokine-cytokine receptor interaction] [Apoptosis] [Natural killer cell mediated cytotoxicity] |
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Pathway (CGAP/BioCarta) | [Induction of apoptosis through DR3 and DR4/5 Death Receptors ] |
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