IDSwiss AccGene NameAliasDescription
8795O14763TNFRSF10BDR5; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5tumor necrosis factor receptor superfamily, member 10b
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracelluar death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.


Gene OntologyGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0007166 cell surface receptor linked signal transduction
GO:0005515 protein binding
GO:0006919 caspase activation
GO:0004872 receptor activity
GO:0016021 integral to membrane
GO:0045569 TRAIL binding
GO:0008656 caspase activator activity
GO:0042981 regulation of apoptosis
GO:0007250 activation of NF-kappaB-inducing kinase
GO:0016020 membrane
GO:0008625 induction of apoptosis via death domain receptors
GO:0007165 signal transduction

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
CASP8in vivo
TRADDin vivo
TNFSF10in vitro;in vivo
CFLARin vitro
FADDin vivo
RIPK1in vivo
MADDin vitro;in vivo
TNFRSF10Ain vitro
TNFRSF10Din vitro;in vivo

Interacting Partner (IntAct)Interaction typeDetection method
TNFSF10 physical interaction, direct interaction pull down, x-ray

Pathway (NetPath)PubMedRegulationExperiment
T Cell Receptor16005866 UpregulationMicroarray
B Cell Receptor11898398,12847549 UpregulationMicroarray
TNF-alpha12754109 UpregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction] [Apoptosis] [Natural killer cell mediated cytotoxicity]

© 2008 National Taiwan Univerisity, Taipei, Taiwan