IDSwiss AccGene NameAliasDescription
8794O14798TNFRSF10CLIT; DCR1; TRID; TRAILR3; TRAIL-R3tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0004888 transmembrane receptor activity
GO:0005887 integral to plasma membrane
GO:0006915 apoptosis
GO:0016020 membrane
GO:0007165 signal transduction

Database cross references

STITCHTNFRSF10C

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TNFSF10in vitro;in vivo
RAP1Ain vivo
SLC27A6yeast 2-hybrid
ZHX1yeast 2-hybrid
LRSAM1yeast 2-hybrid
FAM101Byeast 2-hybrid
APOA1yeast 2-hybrid

Interacting Partner (IntAct)Interaction typeDetection method
APOA1 physical interaction two hybrid pooling
LRSAM1 physical interaction two hybrid pooling
ZHX1 physical interaction two hybrid pooling
SLC25A6 physical interaction two hybrid pooling
MGC45871 physical interaction two hybrid pooling

Pathway (NetPath)PubMedRegulationExperiment
TNF-alpha14641910 UpregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction] [Apoptosis] [Natural killer cell mediated cytotoxicity]


© 2008 National Taiwan Univerisity, Taipei, Taiwan