IDSwiss AccGene NameAliasDescription
8784Q9Y5U5TNFRSF18AITR; GITR; GITR-Dtumor necrosis factor receptor superfamily, member 18
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.


Gene OntologyGO:0016020 membrane
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0006916 anti-apoptosis
GO:0005031 tumor necrosis factor receptor activity
GO:0007165 signal transduction

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TRAF1in vitro;in vivo
TRAF2in vitro;in vivo
TRAF3in vitro;in vivo
TNFSF18in vivo

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

© 2008 National Taiwan Univerisity, Taipei, Taiwan