IDSwiss AccGene NameAliasDescription
8771O95407TNFRSF6BM68; TR6; DCR3; DJ583P15.1.1tumor necrosis factor receptor superfamily, member 6b, decoy
[more aliases]
FunctionThis gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5\' UTR, have been observed for this gene.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0005625 soluble fraction
GO:0008026 ATP-dependent helicase activity
GO:0005515 protein binding
GO:0003676 nucleic acid binding
GO:0006915 apoptosis
GO:0004872 receptor activity
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism
GO:0006916 anti-apoptosis
GO:0005524 ATP binding

Database cross references

STITCHTNFRSF6B

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
FASLGin vivo
TNFSF15in vivo
TNFSF14in vivo

Interacting Partner (IntAct)Interaction typeDetection method
TNFSF14 physical interaction anti tag coip, facs

Pathway (KEGG)[Cytokine-cytokine receptor interaction]


© 2008 National Taiwan Univerisity, Taipei, Taiwan