IDSwiss AccGene NameAliasDescription
8764Q92956TNFRSF14TR2; ATAR; HVEA; HVEM; LIGHTRtumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.


Gene OntologyGO:0005515 protein binding
GO:0007166 cell surface receptor linked signal transduction
GO:0005887 integral to plasma membrane
GO:0006915 apoptosis
GO:0004872 receptor activity
GO:0004888 transmembrane receptor activity
GO:0016020 membrane
GO:0005031 tumor necrosis factor receptor activity
GO:0006955 immune response

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
ESR1in vivo
LTAin vitro
TRAF1in vivo
TNFSF13in vitro
TNFSF14in vivo
HDAC4in vivo
HDAC3in vivo
TRAF5in vivo;yeast 2-hybrid
BTLAin vivo
TRAF2in vitro;in vivo;yeast 2-hybrid
NRIP1in vitro;in vivo;yeast 2-hybrid
TRAF3in vivo
TNFRSF14in vivo
CHD3yeast 2-hybrid
VIMyeast 2-hybrid

Interacting Partner (IntAct)Interaction typeDetection method
TRAF2 physical interaction two hybrid
VIM physical interaction two hybrid pooling
TRAF1 physical interaction pull down
TRAF3 physical interaction pull down
TRAF5 physical interaction two hybrid, coip, pull down
CHD3 physical interaction two hybrid pooling
LTA physical interaction pull down
TNFSF14 physical interaction facs

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

© 2008 National Taiwan Univerisity, Taipei, Taiwan