IDSwiss AccGene NameAliasDescription
8744P41273TNFSF94-1BB-Ltumor necrosis factor (ligand) superfamily, member 9
[more aliases]
FunctionThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF9/4-1BB, which is a costimulatory molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process, and in the generation of cytotoxic T cells. This cytokine is also shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is found to be expressed in various carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.


Gene OntologyGO:0008283 cell proliferation
GO:0007267 cell-cell signaling
GO:0005164 tumor necrosis factor receptor binding
GO:0005887 integral to plasma membrane
GO:0006915 apoptosis
GO:0016020 membrane
GO:0005102 receptor binding
GO:0005615 extracellular space
GO:0007165 signal transduction
GO:0006955 immune response

Database cross references



Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TRAF1in vitro
TRAF2in vitro
TNFRSF9in vivo

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

Pathway (CGAP/BioCarta)[The 4-1BB-dependent immune response ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan