IDSwiss AccGene NameAliasDescription
8743P50591TNFSF10TL2; APO2L; TRAIL; Apo-2Ltumor necrosis factor (ligand) superfamily, member 10
[more aliases]
FunctionThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.


Gene OntologyGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0005164 tumor necrosis factor receptor binding
GO:0007267 cell-cell signaling
GO:0006915 apoptosis
GO:0005887 integral to plasma membrane
GO:0008270 zinc ion binding
GO:0005625 soluble fraction
GO:0016020 membrane
GO:0005102 receptor binding
GO:0046872 metal ion binding
GO:0007165 signal transduction
GO:0006917 induction of apoptosis
GO:0005615 extracellular space
GO:0006955 immune response

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TNFRSF10Ain vitro;in vivo
TNFRSF10Bin vitro;in vivo
TNFRSF10Cin vitro;in vivo
TNFRSF10Din vitro;in vivo
TNFRSF11Bin vitro
TNFSF10in vitro
ACP5yeast 2-hybrid
-yeast 2-hybrid

Interacting Partner (IntAct)Interaction typeDetection method
- physical interaction coip
TNFRSF10A physical interaction pull down
FADD physical interaction pull down, coip
ACP5 physical interaction two hybrid pooling
DKFZP564O0523 physical interaction two hybrid pooling
CASP8 physical interaction pull down, coip
TNFRSF10B physical interaction, direct interaction pull down, x-ray

Pathway (NetPath)PubMedRegulationExperiment
B Cell Receptor12847549 DownregulationMicroarray
IL-212435740 UpregulationNon-Microarray
IL-416054160 DownregulationMicroarray
EGFR116266819 DownregulationMicroarray
TGF-beta Receptor14726474,16135802 DownregulationMicroarray
TNF-alpha12965196 DownregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction] [Apoptosis] [Natural killer cell mediated cytotoxicity]

Pathway (CGAP/BioCarta)[Induction of apoptosis through DR3 and DR4/5 Death Receptors ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan