IDSwiss AccGene NameAliasDescription
8742O43508TNFSF12APO3L; DR3LG; TWEAK; MGC20669; MGC129581tumor necrosis factor (ligand) superfamily, member 12
[more aliases]
FunctionThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.


Gene OntologyGO:0005164 tumor necrosis factor receptor binding
GO:0045766 positive regulation of angiogenesis
GO:0030154 cell differentiation
GO:0006915 apoptosis
GO:0001525 angiogenesis
GO:0005887 integral to plasma membrane
GO:0001938 positive regulation of endothelial cell proliferation
GO:0016020 membrane
GO:0005102 receptor binding
GO:0043542 endothelial cell migration
GO:0048471 perinuclear region
GO:0005615 extracellular space
GO:0007165 signal transduction
GO:0006955 immune response
GO:0006917 induction of apoptosis

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TNFRSF25in vivo
TNFRSF12Ain vivo
AGGF1in vitro;in vivo;yeast 2-hybrid

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

© 2008 National Taiwan Univerisity, Taipei, Taiwan