IDSwiss AccGene NameAliasDescription
8741O75888TNFSF13APRIL; TALL2; TRDL-1; UNQ383/PRO715tumor necrosis factor (ligand) superfamily, member 13
[more aliases]
FunctionThe protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0005164 tumor necrosis factor receptor binding
GO:0016020 membrane
GO:0008284 positive regulation of cell proliferation
GO:0005102 receptor binding
GO:0005615 extracellular space
GO:0007165 signal transduction
GO:0006955 immune response

Database cross references

STITCHTNFSF13

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TNFRSF17in vitro
FASin vitro
FURINin vitro
TNFRSF1Ain vitro
TNFRSF14in vitro
TNFSF13Bin vitro
TNFRSF11Bin vitro
TNFRSF13Bin vitro
SDC2in vivo

Interacting Partner (IntAct)Interaction typeDetection method
TNFRSF13B physical interaction anti tag coip

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

Pathway (CGAP/BioCarta)[TACI and BCMA stimulation of B cell immune responses. ]


© 2008 National Taiwan Univerisity, Taipei, Taiwan