IDSwiss AccGene NameAliasDescription
8740O43557TNFSF14LTg; TR2; HVEMLtumor necrosis factor (ligand) superfamily, member 14
[more aliases]
FunctionThe protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.


Gene OntologyGO:0008588 release of cytoplasmic sequestered NF-kappaB
GO:0005164 tumor necrosis factor receptor binding
GO:0016021 integral to membrane
GO:0043029 T cell homeostasis
GO:0016020 membrane
GO:0043027 caspase inhibitor activity
GO:0005102 receptor binding
GO:0042098 T cell proliferation
GO:0006955 immune response
GO:0005615 extracellular space
GO:0007165 signal transduction
GO:0006917 induction of apoptosis

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
LTBin vitro
LTBRin vitro;in vivo
TNFRSF14in vivo
TNFRSF6Bin vivo

Interacting Partner (IntAct)Interaction typeDetection method
LTB physical interaction facs
TNFRSF14 physical interaction facs
TNFRSF6B physical interaction anti tag coip, facs

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

© 2008 National Taiwan Univerisity, Taipei, Taiwan