IDSwiss AccGene NameAliasDescription
8718Q93038TNFRSF25DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12tumor necrosis factor receptor superfamily, member 25
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. At least 11 alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.


Gene OntologyGO:0005515 protein binding
GO:0007166 cell surface receptor linked signal transduction
GO:0006915 apoptosis
GO:0005887 integral to plasma membrane
GO:0004872 receptor activity
GO:0005886 plasma membrane
GO:0005829 cytosol
GO:0042981 regulation of apoptosis
GO:0004888 transmembrane receptor activity
GO:0016020 membrane
GO:0008624 induction of apoptosis by extracellular signals
GO:0006955 immune response
GO:0005031 tumor necrosis factor receptor activity
GO:0007165 signal transduction

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
MAPK1in vitro;in vivo
TNFSF12in vivo
BAG4in vivo;yeast 2-hybrid
TNFSF15in vivo
TRAF2in vivo
TNFRSF1Ayeast 2-hybrid
TRADDin vivo;yeast 2-hybrid

Pathway (NetPath)PubMedRegulationExperiment
IL-212459040 DownregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

Pathway (CGAP/BioCarta)[Induction of apoptosis through DR3 and DR4/5 Death Receptors ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan