IDSwiss AccGene NameAliasDescription
8600O14788TNFSF11ODF; OPGL; sOdf; RANKL; TRANCE; hRANKL2tumor necrosis factor (ligand) superfamily, member 11
[more aliases]
FunctionThis gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.


Gene OntologyGO:0005164 tumor necrosis factor receptor binding
GO:0030316 osteoclast differentiation
GO:0030154 cell differentiation
GO:0005887 integral to plasma membrane
GO:0005576 extracellular region
GO:0016020 membrane
GO:0004872 receptor activity
GO:0005615 extracellular space
GO:0006955 immune response

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
AKT1in vitro;in vivo
NFKBIAin vitro;in vivo
NFKB1in vitro;in vivo
MAPK1in vitro;in vivo
MAPK3in vitro;in vivo
MAPK8in vivo
TRAF6in vitro;in vivo
TNFSF11in vitro;in vivo
TNFRSF11Ain vivo
MMP7in vitro
MMP3in vitro
ADAM17in vivo
ADAM19in vitro
TNFRSF11Bin vivo
MMP1in vivo

Pathway (NetPath)PubMedRegulationExperiment
Hedgehog10208865 UpregulationNon-Microarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

Pathway (CGAP/BioCarta)[Bone Remodelling ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan