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| ID | Swiss Acc | Gene Name | Alias | Description | 7293 | P43489 | TNFRSF4 | OX40; ACT35; CD134; TXGP1L | tumor necrosis factor receptor superfamily, member 4 |
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| [more aliases] |
| Function | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. |
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| Associations | TCM-Gene | TCM-Gene-Disease |
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| Gene Ontology | GO:0016020 membrane GO:0005887 integral to plasma membrane GO:0004872 receptor activity GO:0006955 immune response GO:0005031 tumor necrosis factor receptor activity |
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Database cross references
| STITCH | TNFRSF4 |
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Integrated protein interaction and pathway information
| Interacting Partners (HPRD) | Experiment |
|---|---|
| TRAF2 | in vivo;yeast 2-hybrid |
| TRAF3 | in vivo;yeast 2-hybrid |
| TRAF5 | in vitro;in vivo |
| TNFSF4 | in vivo |
| TRAF1 | in vivo |
| TNFRSF9 | in vivo |
| TRAF4 | in vivo |
| SIVA1 | in vitro |
| Pathway (NetPath) | PubMed | Regulation | Experiment |
|---|---|---|---|
| IL-2 | 12459040 | Upregulation | Microarray |
| Wnt | 14707084 | Downregulation | Microarray |
| Pathway (KEGG) | [Cytokine-cytokine receptor interaction] |
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| Pathway (CGAP/BioCarta) | [OX40 Signaling Pathway ] |
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