IDSwiss AccGene NameAliasDescription
7293P43489TNFRSF4OX40; ACT35; CD134; TXGP1Ltumor necrosis factor receptor superfamily, member 4
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.


Gene OntologyGO:0016020 membrane
GO:0005887 integral to plasma membrane
GO:0004872 receptor activity
GO:0006955 immune response
GO:0005031 tumor necrosis factor receptor activity

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TRAF2in vivo;yeast 2-hybrid
TRAF3in vivo;yeast 2-hybrid
TRAF5in vitro;in vivo
TNFSF4in vivo
TRAF1in vivo
TNFRSF9in vivo
TRAF4in vivo
SIVA1in vitro

Pathway (NetPath)PubMedRegulationExperiment
IL-212459040 UpregulationMicroarray
Wnt14707084 DownregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

Pathway (CGAP/BioCarta)[OX40 Signaling Pathway ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan