IDSwiss AccGene NameAliasDescription
7292P23510TNFSF4GP34; OX4OL; TXGP1; CD134L; OX-40Ltumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)
[more aliases]
FunctionThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.


Gene OntologyGO:0007267 cell-cell signaling
GO:0005164 tumor necrosis factor receptor binding
GO:0016020 membrane
GO:0005887 integral to plasma membrane
GO:0008284 positive regulation of cell proliferation
GO:0005102 receptor binding
GO:0005615 extracellular space
GO:0007165 signal transduction
GO:0006955 immune response

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TNFRSF4in vivo
TRAF2yeast 2-hybrid

Pathway (NetPath)PubMedRegulationExperiment
TGF-beta Receptor14726474 UpregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

Pathway (CGAP/BioCarta)[OX40 Signaling Pathway ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan