IDSwiss AccGene NameAliasDescription
7133P20333TNFRSF1Bp75; TBPII; TNFBR; TNFR2; CD120b; TNFR80; TNF-R75; p75TNFR; TNF-R-IItumor necrosis factor receptor superfamily, member 1B
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0005515 protein binding
GO:0016020 membrane
GO:0006915 apoptosis
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0005031 tumor necrosis factor receptor activity
GO:0019221 cytokine and chemokine mediated signaling pathway

Database cross references

PharmGKBPA36610

STITCHTNFRSF1B

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
KRT18in vitro
LTAin vivo
CSNK1A1in vivo
STAT1in vitro;in vivo
CAV1in vivo
TRAF3in vivo
TTRAPin vivo;yeast 2-hybrid
TRAIPin vitro;in vivo;yeast 2-hybrid
HIVEP3in vivo
TRAF1in vitro;in vivo;yeast 2-hybrid
TRAF2in vitro;in vivo;yeast 2-hybrid
BMXin vitro
TNFin vitro
FANCD2in vitro

Interacting Partners (NetPath)TNF [7664431,2158863 ] FANCD2 [14743216 ] STAT1 [10848577 ] TRAF2 [7544915,14743216 ]

Interacting Partner (IntAct)Interaction typeDetection method
PHGDH physical interaction tap
EEF1A2 physical interaction tap
- physical interaction tap
TNF physical interaction tap
FKSG30 physical interaction tap
- physical interaction tap
RCN2 physical interaction tap
PDCD8 physical interaction tap
CCT1 physical interaction tap
RPS27 physical interaction tap
RPS18 physical interaction tap
LOC63929 physical interaction tap
MYLK2 physical interaction tap
MYH10 physical interaction tap
FANCD2 physical interaction tap
HSPA8 physical interaction tap
RPS3 physical interaction tap
RPS16 physical interaction tap
CaMIII physical interaction tap
XPO1 physical interaction tap
DNAJA3 physical interaction tap
SEC61A1 physical interaction tap
RPS14 physical interaction tap
- physical interaction tap
GCN1L1 physical interaction tap
ABC1 physical interaction tap
SLC25A5 physical interaction tap
PFKP physical interaction tap
DBT physical interaction tap
COPB physical interaction tap
ACTG1 physical interaction tap
KPNB1 physical interaction tap
tubb5 physical interaction tap
SLC25A3 physical interaction tap
SLC1A5 physical interaction tap
SLC1A3 physical interaction tap
DNAJA1 physical interaction tap
EPPK1 physical interaction tap
HSPA5 physical interaction tap
CLTC physical interaction tap
- physical interaction tap
MYH9 physical interaction tap
TRAF1 physical interaction two hybrid
TUFM physical interaction tap
HSP70-1 physical interaction tap
SLC25A4 physical interaction tap
ATP1A1 physical interaction tap
XPO5 physical interaction tap
KIAA1794 physical interaction tap
BAG2 physical interaction tap
GAPD physical interaction tap
TUBB4 physical interaction tap
PRKDC physical interaction tap
TRAF2 physical interaction two hybrid, tap
XPOT physical interaction tap
CAD physical interaction tap
IPO7 physical interaction tap
RPL38 physical interaction tap
ATP5A1 physical interaction tap
ATP2A2 physical interaction tap
SSR4 physical interaction tap
HAX1 physical interaction tap
TRIP13 physical interaction tap
- physical interaction tap
CDIPT physical interaction tap
FLNA physical interaction tap
VIM physical interaction tap
HSPA6 physical interaction tap
HSPA1L physical interaction tap
HNRPU physical interaction tap
SLC25A11 physical interaction tap
MAD2L1 physical interaction tap
CSE1L physical interaction tap
TRA1 physical interaction tap
DDB1 physical interaction tap
IRS4 physical interaction tap
ATP2A1 physical interaction tap
ubc1 physical interaction tap
TNFRSF1B physical interaction tap
KIAA0103 physical interaction tap
SLC25A1 physical interaction tap
HNRPC physical interaction tap
DDOST physical interaction tap
RP11-506K6.1 physical interaction tap
KCTD12 physical interaction tap
CBWD2 physical interaction tap
C1QBP physical interaction tap
TUBA2 physical interaction tap
HSPC121 physical interaction tap
SERPINB3 physical interaction tap
FLJ10709 physical interaction tap
IPO8 physical interaction tap
MYO6 physical interaction tap
GBF1 physical interaction tap
RPL23 physical interaction tap
SLC25A6 physical interaction tap
HSPA9B physical interaction tap

Pathway (NetPath)PubMedRegulationExperiment
B Cell Receptor11898398 DownregulationMicroarray
IL-212459040,12435740 UpregulationMicroarray
IL-315653694 DownregulationNon-Microarray
TNF-alpha8381414 UpregulationNon-Microarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction] [Adipocytokine signaling pathway]

Pathway (CGAP/BioCarta)[TNFR2 Signaling Pathway ]


© 2008 National Taiwan Univerisity, Taipei, Taiwan