IDSwiss AccGene NameAliasDescription
7132P19438TNFRSF1AFPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; MGC19588tumor necrosis factor receptor superfamily, member 1A
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0005515 protein binding
GO:0005887 integral to plasma membrane
GO:0006915 apoptosis
GO:0004872 receptor activity
GO:0050729 positive regulation of inflammatory response
GO:0019221 cytokine and chemokine mediated signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0006693 prostaglandin metabolism
GO:0004871 signal transducer activity
GO:0006954 inflammatory response
GO:0016020 membrane
GO:0005576 extracellular region
GO:0007165 signal transduction
GO:0005031 tumor necrosis factor receptor activity

Database cross references

STITCHTNFRSF1A

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
GRB2in vivo
HSP90AA1in vitro
JAK2in vitro;in vivo
JAK1in vitro;in vivo
PTPN11in vivo
LTAin vivo
PTPN6in vivo
TNFRSF1Ain vitro;yeast 2-hybrid
IKBKGin vivo
STAT1in vitro
CHUKin vivo
DAPK1in vitro;in vivo
TRAF1in vivo
CASP7in vitro
CASP10in vitro
TRAF2in vivo
PIP5K2Bin vitro;in vivo
RIPK1in vivo;yeast 2-hybrid
RIPK2in vivo
MADDin vitro
BAG4in vivo;yeast 2-hybrid
TNFSF13in vitro
PSMD2in vitro;yeast 2-hybrid
-in vivo
UBE2Iin vitro;yeast 2-hybrid
NSMAFin vitro;in vivo;yeast 2-hybrid
TRPC4APin vivo
RIPK3in vivo
TRADDin vitro;in vivo;yeast 2-hybrid
MAPK1in vitro
LTBin vitro
IKBKBin vitro
GNB2L1in vitro
MOAP1in vivo
SUMO1in vitro;in vivo;yeast 2-hybrid
RASSF1in vivo
TNFin vitro
FANCD2in vitro
PTK2in vivo
TNFRSF25yeast 2-hybrid
MYOCyeast 2-hybrid
TRAP1in vitro;yeast 2-hybrid
ERN1in vivo

Interacting Partners (NetPath)TNF [10634209,14743216 ] DAP [10187798 ] FANCD2 [14743216 ] NSMAF [12391233 ] PTK2 [12748169 ] STAT1 [10848577 ] TRADD [7758105,8791485,8943045,10634209 ] UBE2I [9563508 ] BAG4 [9915703,10634209,12748303 ] TRPC4AP [14585990 ]

Interacting Partner (IntAct)Interaction typeDetection method
MYO6 physical interaction tap
TRAF2 physical interaction anti bait coip, coip
HSPA9B physical interaction tap
ATP2A2 physical interaction tap
- physical interaction tap
SLC25A5 physical interaction tap
TRADD physical interaction two hybrid, pull down, anti bait coip, coip
rps27a physical interaction tap
TNFRSF1A physical interaction two hybrid, tap
- physical interaction tap
CANX physical interaction tap
DNAJB12 physical interaction tap
- physical interaction tap
ubc1 physical interaction tap
CLTCL1 physical interaction tap
tubb5 physical interaction tap
ACTG1 physical interaction tap
SLC1A5 physical interaction tap
HIST1H2BB physical interaction tap
SLC25A6 physical interaction tap
FANCD2 physical interaction tap
CaMIII physical interaction tap
DDOST physical interaction tap
RP11-506K6.1 physical interaction tap
HSPA8 physical interaction tap
SEL1L physical interaction tap
HIST3H3 physical interaction tap
AFG3L2 physical interaction tap
RPS3 physical interaction tap
IPO8 physical interaction tap
DNAJA3 physical interaction tap
SLC25A3 physical interaction tap
HIST1H2AE physical interaction tap
TUBB6 physical interaction tap
HSPA5 physical interaction tap
PRO1855 physical interaction tap
- physical interaction tap
MLCB physical interaction tap
TUBA2 physical interaction tap
SEC61A1 physical interaction tap
ATP1A1 physical interaction tap
RUVBL1 physical interaction tap
ATP5A1 physical interaction tap
MYH10 physical interaction tap
UBA52 physical interaction tap
C1QBP physical interaction tap
RPL23 physical interaction tap
MYL6 physical interaction tap
DNAJA1 physical interaction tap
CLTC physical interaction tap
HSP70-1 physical interaction tap
RCN2 physical interaction tap
hSF21 physical interaction tap
XPOT physical interaction tap
CDIPT physical interaction tap
GCN1L1 physical interaction tap
RPS27 physical interaction tap
SSR4 physical interaction tap
HSPA6 physical interaction tap
TUBB4 physical interaction tap
CAD physical interaction tap
TNF physical interaction, direct interaction anti tag coip, anti bait coip, tap
HAX1 physical interaction tap
BIRC2 physical interaction anti bait coip, coip
HSPA1L physical interaction tap
pfkl physical interaction tap
FLJ10709 physical interaction tap
- physical interaction tap
HIST1H4A physical interaction tap
PRKDC physical interaction tap
BAG2 physical interaction tap
RPS16 physical interaction tap
NAP1L1 physical interaction tap
EPPK1 physical interaction tap
ARTS1 physical interaction two hybrid
MYH9 physical interaction tap
RARS physical interaction tap
HADHA physical interaction tap

Pathway (NetPath)PubMedRegulationExperiment
IL-315653694 DownregulationNon-Microarray
Notch15919944 UpregulationMicroarray
Kit Receptor12086670 UpregulationMicroarray
TGF-beta Receptor11267935 DownregulationMicroarray

Pathway (KEGG)[MAPK signaling pathway] [Cytokine-cytokine receptor interaction] [Apoptosis] [Adipocytokine signaling pathway]

Pathway (CGAP/BioCarta)[Ceramide Signaling Pathway ] [HIV-I Nef: negative effector of Fas and TNF ] [Keratinocyte Differentiation ] [NF-kB Signaling Pathway ] [Regulation of transcriptional activity by PML ] [Acetylation and Deacetylation of RelA in The Nucleus ] [SODD/TNFR1 Signaling Pathway ] [TNF/Stress Related Signaling ] [Chaperones modulate interferon Signaling Pathway ] [TNFR1 Signaling Pathway ]


© 2008 National Taiwan Univerisity, Taipei, Taiwan