IDSwiss AccGene NameAliasDescription
7128P21580TNFAIP3A20; TNFA1P2; MGC104522tumor necrosis factor, alpha-induced protein 3
[more aliases]
FunctionThis gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.


Gene OntologyGO:0005515 protein binding
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0005634 nucleus
GO:0006915 apoptosis
GO:0006512 ubiquitin cycle
GO:0003677 DNA binding
GO:0008270 zinc ion binding
GO:0008234 cysteine-type peptidase activity
GO:0006916 anti-apoptosis
GO:0046872 metal ion binding

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
YWHAHin vitro;in vivo;yeast 2-hybrid
TNFAIP3in vitro;in vivo;yeast 2-hybrid
IKBKGin vitro;in vivo;yeast 2-hybrid
CHUKin vitro;in vivo
YWHAZyeast 2-hybrid
YWHABin vitro;in vivo;yeast 2-hybrid
TRAF1in vivo;yeast 2-hybrid
TRAF2in vivo;yeast 2-hybrid
TRAF6in vivo
IKBKBin vitro;in vivo
YWHAEin vivo
TAX1BP1in vivo;yeast 2-hybrid
YWHAGin vivo;yeast 2-hybrid
TNIP1in vivo;yeast 2-hybrid
TNIP2in vivo;yeast 2-hybrid
RIPK1in vitro;in vivo
TICAM1in vivo
LAPTM5yeast 2-hybrid
RNF11yeast 2-hybrid
ZFAND5in vivo

Interacting Partners (NetPath)IKBKG [10755617 ] TRAF1 [8692885 ] TRAF2 [8692885 ] TNIP1 [10385526 ] TNIP2 [11390377 ] ZA20D2 [14754897 ]

Interacting Partner (IntAct)Interaction typeDetection method
TRAF6 physical interaction anti tag coip

Pathway (NetPath)PubMedRegulationExperiment
B Cell Receptor12847549 DownregulationMicroarray
IL-115336943,14673796 UpregulationMicroarray
EGFR116266819 UpregulationMicroarray
TGF-beta Receptor14726474 DownregulationMicroarray
TNF-alpha15454581,15722553 DownregulationMicroarray

Pathway (CGAP/BioCarta)[CD40L Signaling Pathway ] [NF-kB Signaling Pathway ] [TNFR2 Signaling Pathway ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan