IDSwiss AccGene NameAliasDescription
6868P78536ADAM17TACE; cSVP; CD156b; MGC71942ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
[more aliases]
FunctionThis gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.


Gene OntologyGO:0008270 zinc ion binding
GO:0007219 Notch signaling pathway
GO:0005515 protein binding
GO:0007267 cell-cell signaling
GO:0016020 membrane
GO:0005887 integral to plasma membrane
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
GO:0006508 proteolysis

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
NOTCH1in vitro;in vivo
TNFin vitro;in vivo
TIMP3in vitro
ERBB4in vitro
DLG1in vitro;in vivo;yeast 2-hybrid
MAD2L1in vitro;yeast 2-hybrid
MAD2L2in vitro;in vivo
-in vivo
TNFSF11in vivo
PTPN3in vitro;in vivo;yeast 2-hybrid
TGFAin vitro
FHL2in vitro;in vivo;yeast 2-hybrid

Interacting Partner (IntAct)Interaction typeDetection method
MAD2L1 physical interaction two hybrid, pull down, coip

Pathway (NetPath)PubMedRegulationExperiment
TNF-alpha14641910 UpregulationMicroarray

Pathway (KEGG)[Notch signaling pathway] [Epithelial cell signaling in Helicobacter pylori infection]

Pathway (CGAP/BioCarta)[g-Secretase mediated ErbB4 Signaling Pathway ] [Proteolysis and Signaling Pathway of Notch ] [Presenilin action in Notch and Wnt signaling ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan