IDSwiss AccGene NameAliasDescription
608Q02223TNFRSF17BCM; BCMAtumor necrosis factor receptor superfamily, member 17
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0008283 cell proliferation
GO:0005554 molecular function unknown
GO:0005515 protein binding
GO:0007275 development
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0005886 plasma membrane
GO:0008372 cellular component unknown
GO:0019735 antimicrobial humoral response (sensu Vertebrata)
GO:0006955 immune response
GO:0007165 signal transduction
GO:0000004 biological process unknown

Database cross references

STITCHTNFRSF17

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TRAF1in vivo
TRAF2in vivo
TRAF3in vivo
TNFSF13Bin vitro;in vivo
TNFSF13in vitro

Interacting Partner (IntAct)Interaction typeDetection method
TNFSF13B physical interaction saturation binding

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

Pathway (CGAP/BioCarta)[TACI and BCMA stimulation of B cell immune responses. ]


© 2008 National Taiwan Univerisity, Taipei, Taiwan