IDSwiss AccGene NameAliasDescription
55872Q96KB5PBKSPK; TOPK; Nori-3; FLJ14385PDZ binding kinase
[more aliases]
FunctionThe protein encoded by this gene is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.


Gene OntologyGO:0005515 protein binding
GO:0004674 protein serine/threonine kinase activity
GO:0016740 transferase activity
GO:0000166 nucleotide binding
GO:0007067 mitosis
GO:0005524 ATP binding
GO:0006468 protein amino acid phosphorylation
GO:0008372 cellular component unknown

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
CDC2in vitro
CCNB1in vitro
RAF1yeast 2-hybrid
TRIM37yeast 2-hybrid
ARAFin vitro
DLG1in vitro;yeast 2-hybrid
GPS2yeast 2-hybrid
SMAD4in vivo
GPRASP1yeast 2-hybrid
KIAA1377yeast 2-hybrid

Interacting Partner (IntAct)Interaction typeDetection method
ARAF physical interaction two hybrid
TRIM37 physical interaction two hybrid pooling
KIAA1377 physical interaction two hybrid pooling
RAF1 physical interaction two hybrid
GPS2 physical interaction two hybrid pooling
GASP physical interaction two hybrid pooling

© 2008 National Taiwan Univerisity, Taipei, Taiwan