IDSwiss AccGene NameAliasDescription
55504Q9NS68TNFRSF19TAJ; TROY; TAJ-alphatumor necrosis factor receptor superfamily, member 19
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0005515 protein binding
GO:0006915 apoptosis
GO:0016020 membrane
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0005031 tumor necrosis factor receptor activity
GO:0006917 induction of apoptosis
GO:0007254 JNK cascade

Database cross references

STITCHTNFRSF19

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TRAF1in vivo
TRAF6in vivo
TRAF5in vivo
TRAF2in vivo
TRAF3in vivo

Interacting Partner (IntAct)Interaction typeDetection method
TRAF2 physical interaction anti tag coip
TRAF5 physical interaction anti tag coip
TRAF1 physical interaction anti tag coip

Pathway (KEGG)[Cytokine-cytokine receptor interaction]


© 2008 National Taiwan Univerisity, Taipei, Taiwan