IDSwiss AccGene NameAliasDescription
4982O00300TNFRSF11BOPG; TR1; OCIF; MGC29565tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand (TNFSF11/OPGL), both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0005515 protein binding
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0006915 apoptosis
GO:0004872 receptor activity
GO:0001501 skeletal development
GO:0007165 signal transduction

Database cross references

STITCHTNFRSF11B

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TNFSF10in vitro
TNFSF13in vitro
VWFin vivo
THBS1in vivo
VTNin vivo
FN1in vivo
TNFSF11in vivo

Pathway (NetPath)PubMedRegulationExperiment
IL-115381094 UpregulationMicroarray
IL-215735688 UpregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction]


© 2008 National Taiwan Univerisity, Taipei, Taiwan