IDSwiss AccGene NameAliasDescription
3604Q07011TNFRSF9ILA; 4-1BB; CD137; CDw137; MGC2172tumor necrosis factor receptor superfamily, member 9
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.


Gene OntologyGO:0008285 negative regulation of cell proliferation
GO:0016020 membrane
GO:0005887 integral to plasma membrane
GO:0004872 receptor activity
GO:0006955 immune response
GO:0006917 induction of apoptosis

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TRAF1in vitro;yeast 2-hybrid
TRAF2in vitro;yeast 2-hybrid
TRAF3in vitro;yeast 2-hybrid
TNFSF9in vivo
PPIL5in vitro;yeast 2-hybrid
TNFRSF4in vivo

Pathway (NetPath)PubMedRegulationExperiment
TNF-alpha15454581 UpregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

Pathway (CGAP/BioCarta)[The 4-1BB-dependent immune response ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan