IDSwiss AccGene NameAliasDescription
27242O75509TNFRSF21DR6; BM-018; MGC31965tumor necrosis factor receptor superfamily, member 21
[more aliases]
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0005515 protein binding
GO:0016020 membrane
GO:0006915 apoptosis
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0007165 signal transduction

Database cross references

STITCHTNFRSF21

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TRADDin vivo

Pathway (KEGG)[Cytokine-cytokine receptor interaction]


© 2008 National Taiwan Univerisity, Taipei, Taiwan