IDSwiss AccGene NameAliasDescription
23495O14836TNFRSF13BTACI; MGC39952; MGC133214; TNFRSF14Btumor necrosis factor receptor superfamily, member 13B
[more aliases]
FunctionThe protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0007166 cell surface receptor linked signal transduction
GO:0005515 protein binding
GO:0016020 membrane
GO:0005887 integral to plasma membrane
GO:0004872 receptor activity
GO:0006955 immune response

Database cross references

STITCHTNFRSF13B

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
CAMLGin vivo;yeast 2-hybrid
TRAF6in vitro;in vivo
TRAF5in vitro;in vivo
TRAF2in vitro;in vivo;yeast 2-hybrid
TNFSF13Bin vitro;in vivo
TNFSF13in vitro

Interacting Partner (IntAct)Interaction typeDetection method
TNFSF13 physical interaction anti tag coip
TNFSF13B physical interaction, direct interaction saturation binding, facs, anti tag coip, spr

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

Pathway (CGAP/BioCarta)[TACI and BCMA stimulation of B cell immune responses. ]


© 2008 National Taiwan Univerisity, Taipei, Taiwan