IDSwiss AccGene NameAliasDescription
115650Q96RJ3TNFRSF13CBAFFR; BAFF-Rtumor necrosis factor receptor superfamily, member 13C
[more aliases]
FunctionB cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0016020 membrane
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0006955 immune response

Database cross references

STITCHTNFRSF13C

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TNFSF13Bin vitro;in vivo
TNFRSF13Cin vivo
TRAF3IP3in vitro;yeast 2-hybrid

Pathway (NetPath)PubMedRegulationExperiment
B Cell Receptor14564011,12794106 UpregulationNon-Microarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

Pathway (CGAP/BioCarta)[TACI and BCMA stimulation of B cell immune responses. ]


© 2008 National Taiwan Univerisity, Taipei, Taiwan