IDSwiss AccGene NameAliasDescription
10673Q9Y275TNFSF13BBAFF; BLYS; TALL1; THANK; ZTNF4; TALL-1; TNFSF20; delta BAFFtumor necrosis factor (ligand) superfamily, member 13b
[more aliases]
FunctionThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells.


Gene OntologyGO:0008283 cell proliferation
GO:0005164 tumor necrosis factor receptor binding
GO:0005887 integral to plasma membrane
GO:0008284 positive regulation of cell proliferation
GO:0005625 soluble fraction
GO:0016020 membrane
GO:0005102 receptor binding
GO:0005615 extracellular space
GO:0007165 signal transduction
GO:0006955 immune response

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
TNFRSF17in vitro;in vivo
TNFSF13Bin vitro
TNFSF13in vitro
TNFRSF13Bin vitro;in vivo
TNFRSF13Cin vitro;in vivo

Interacting Partner (IntAct)Interaction typeDetection method
TNFRSF17 physical interaction saturation binding
TNFRSF13B physical interaction, direct interaction saturation binding, facs, anti tag coip, spr

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

Pathway (CGAP/BioCarta)[TACI and BCMA stimulation of B cell immune responses. ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan