IDSwiss AccGene NameAliasDescription
925P01732CD8ACD8; MAL; p32; Leu2CD8 antigen, alpha polypeptide (p32)

Other aliasesCD8; CD8A; Leu2; CD 8; CD-8; Leu 2; CD 8A; Leu-2; CD 8 A; CD8alpha; CD 8 alpha; CD8a antigen; CD8a molecule; CD 8 a antigen; CD 8 a molecule; CD8 antigen, alphapolypeptide (p32); CD8 antigen,alpha polypeptide (p32); CD8 antigen, alpha polypeptide (p32); CD 8 antigen, alphapolypeptide (p 32); CD 8 antigen,alpha polypeptide (p 32); CD 8 antigen, alpha polypeptide (p 32); T-lymphocyte differentiation antigen T8/Leu-2; T-lymphocyte differentiation antigen T 8/ Leu-2; T-cell surface glycoprotein CD8alpha chain precursor; T-cell surface glycoprotein CD8 alpha chain precursor; T-cell surface glycoprotein CD 8 alpha chain precursor

FunctionThe CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0019882 antigen presentation
GO:0005515 protein binding
GO:0005887 integral to plasma membrane
GO:0042110 T cell activation
GO:0016066 cellular defense response (sensu Vertebrata)
GO:0042101 T cell receptor complex
GO:0042288 MHC class I protein binding
GO:0016020 membrane
GO:0015026 coreceptor activity

Database cross references

STITCHCD8A

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
HLA-Ain vitro
HLA-Bin vitro
HLA-Cin vitro
HLA-Gin vitro;in vivo
HLA-Ein vitro
LGALS1in vitro
PTPRCin vivo
CD8Bin vitro;in vivo
CD3Din vitro;in vivo
SFRS1in vitro
LATin vivo
-in vitro;in vivo;yeast 2-hybrid
LCKin vitro
CD8Ain vitro
B2Min vitro

Interacting Partners (NetPath)LCK [3262426 ] LAT [10562325 ]

Pathway (KEGG)[Cell adhesion molecules (CAMs)] [Antigen processing and presentation] [Hematopoietic cell lineage] [T cell receptor signaling pathway]

Pathway (CGAP/BioCarta)[IL 17 Signaling Pathway ] [Regulation of hematopoiesis by cytokines ] [T Cytotoxic Cell Surface Molecules ]


© 2008 National Taiwan Univerisity, Taipei, Taiwan