IDSwiss AccGene NameAliasDescription
81O43707ACTN4FSGS; FSGS1actinin, alpha 4
[more aliases]
Function Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.


Gene OntologyGO:0005737 cytoplasm
GO:0005509 calcium ion binding
GO:0006928 cell motility
GO:0051017 actin filament bundle formation
GO:0005634 nucleus
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0015629 actin cytoskeleton

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
ACTC1in vivo
SERPINE1in vivo;yeast 2-hybrid
COL17A1in vivo;yeast 2-hybrid
GSNin vitro
ITGB1in vitro
NEBin vitro
NOS2Ain vitro
PTPN11in vitro;in vivo
MYOZ2yeast 2-hybrid
MYOZ1yeast 2-hybrid
ATP6V1B1in vivo
ACTN3in vivo
LRRC7in vitro;yeast 2-hybrid
MAGI1in vitro
CAMK2Gin vitro;in vivo;yeast 2-hybrid
TRIM3in vivo;yeast 2-hybrid
SLC9A3R2in vitro;in vivo
USP6NLin vitro;in vivo
PDLIM1in vitro;in vivo
PTPN6in vitro
CAMK2Ain vitro;yeast 2-hybrid
CAMK2Bin vitro;yeast 2-hybrid
ADORA2Ain vitro;yeast 2-hybrid
SACSyeast 2-hybrid
COILyeast 2-hybrid
SLC2A4in vivo

Interacting Partner (IntAct)Interaction typeDetection method
PDLIM1 physical interaction two hybrid pooling
RIPK3 physical interaction tap
MYOZ physical interaction two hybrid pooling
MYOZ2 physical interaction two hybrid pooling
COIL physical interaction two hybrid
SACS physical interaction two hybrid
TJP1 physical interaction, colocalization pull down, anti bait coip, fluorescence imaging
CDH1 physical interaction spr, pull down
GRB2 physical interaction pull down
MAP3K3 physical interaction tap

Pathway (KEGG)[Focal adhesion] [Adherens junction] [Tight junction] [Leukocyte transendothelial migration] [Regulation of actin cytoskeleton]

© 2008 National Taiwan Univerisity, Taipei, Taiwan