IDSwiss AccGene NameAliasDescription
7130P98066TNFAIP6TSG6tumor necrosis factor, alpha-induced protein 6

Other aliasesTSG6; TSG-6; TSG 6; TNFAIP6; TNFAIP 6; TNFAIP-6; TNF, alphainduced protein 6; TNF,alpha-induced protein 6; Hyaluronate-binding protein; TNF, alpha-induced protein 6; TNF- stimulated gene 6 protein; tumor necrosis factor,alpha-induced protein 6; tumor necrosis factor, alphainduced protein 6; tumor necrosis factor, alpha-induced protein 6; tumor necrosis factor- stimulated gene 6 protein; Tumor necrosis factor-inducible protein TSG-6 precursor

FunctionThe protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. The expression of this gene can be induced by tumor necrosis factor alpha and interleukin-1. The expression can also be induced by mechanical stimuli in vascular smooth muscle cells, and is found to be correlated with proteoglycan synthesis and aggregation.


Gene OntologyGO:0005515 protein binding
GO:0007267 cell-cell signaling
GO:0006954 inflammatory response
GO:0005540 hyaluronic acid binding
GO:0005576 extracellular region
GO:0007165 signal transduction
GO:0007155 cell adhesion

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
AGC1in vitro
THBS1in vitro

Pathway (NetPath)PubMedRegulationExperiment
IL-116264101,15950496 UpregulationMicroarray
TGF-beta Receptor14726474,15571627 UpregulationMicroarray

© 2008 National Taiwan Univerisity, Taipei, Taiwan