IDSwiss AccGene NameAliasDescription
7124P01375TNFDIF; TNFA; TNFSF2; TNF-alphatumor necrosis factor (TNF superfamily, member 2)
[more aliases]
FunctionThis gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.


Gene OntologyGO:0005515 protein binding
GO:0005625 soluble fraction
GO:0005164 tumor necrosis factor receptor binding
GO:0007267 cell-cell signaling
GO:0006915 apoptosis
GO:0009615 response to virus
GO:0016020 membrane
GO:0016021 integral to membrane
GO:0006355 regulation of transcription, DNA-dependent
GO:0009611 response to wounding
GO:0007159 leukocyte adhesion
GO:0006916 anti-apoptosis
GO:0007165 signal transduction
GO:0006955 immune response
GO:0005615 extracellular space
GO:0051092 activation of NF-kappaB transcription factor

Database cross references



Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
-in vivo
DCNin vitro
BGNin vitro
TRAF2in vivo
MMP17in vitro
ADAM9in vitro
ADAM17in vitro;in vivo
PRTN3in vivo
IFNGin vitro;in vivo
TNFin vitro
TNFRSF1Ain vitro
TNFRSF1Bin vitro
PDIK1Lin vitro;in vivo

Interacting Partners (NetPath)TNFRSF1A [10634209,14743216 ] TNFRSF1B [7664431,2158863 ]

Interacting Partner (IntAct)Interaction typeDetection method
TNFRSF1B physical interaction tap
BIRC2 physical interaction anti tag coip
TRAF2 physical interaction anti tag coip
TRADD physical interaction anti tag coip
RIPK1 physical interaction anti tag coip
TNFRSF1A physical interaction, direct interaction anti tag coip, anti bait coip, tap

Pathway (NetPath)PubMedRegulationExperiment
T Cell Receptor11516335 DownregulationMicroarray,Non-Microarray
B Cell Receptor16424387 UpregulationNon-Microarray
IL-29538144 UpregulationNon-Microarray
IL-38038234 UpregulationNon-Microarray
IL-415869882 DownregulationNon-Microarray
Kit Receptor11032806 UpregulationNon-Microarray

Pathway (KEGG)[MAPK signaling pathway] [Cytokine-cytokine receptor interaction] [Apoptosis] [TGF-beta signaling pathway] [Toll-like receptor signaling pathway] [Hematopoietic cell lineage]

Pathway (CGAP/BioCarta)[Cadmium induces DNA synthesis and proliferation in macrophages ] [Cytokine Network ] [Free Radical Induced Apoptosis ] [Adhesion and Diapedesis of Granulocytes ] [HIV-I Nef: negative effector of Fas and TNF ] [Stress Induction of HSP Regulation ] [IL-10 Anti-inflammatory Signaling Pathway ] [Signal transduction through IL1R ] [Cytokines and Inflammatory Response ] [Keratinocyte Differentiation ] [Cells and Molecules involved in local acute inflammatory response ] [Msp/Ron Receptor Signaling Pathway ] [NF-kB Signaling Pathway ] [NFkB activation by Nontypeable Hemophilus influenzae ] [Regulation of transcriptional activity by PML ] [Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) ] [Acetylation and Deacetylation of RelA in The Nucleus ] [SODD/TNFR1 Signaling Pathway ] [TNF/Stress Related Signaling ] [Chaperones modulate interferon Signaling Pathway ] [TNFR1 Signaling Pathway ] [Visceral Fat Deposits and the Metabolic Syndrome ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan