IDSwiss AccGene NameAliasDescription
6347P13500CCL2HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30; MGC9434; GDCF-2 HC11chemokine (C-C motif) ligand 2

Other aliasesCCL2; MCP1; HC11; MCAF; MCP-1; SCYA2; HC-11; GDCF2; CCL-2; HC 11; CCL 2; MCP 1; GDCF 2; GDCF-2; SMC-CF; SCYA-2; SCYA 2; MGC9434; HSMCR30; HSMCR-30; MGC 9434; MGC-9434; HSMCR 30; GDCF-2 HC11; GDCF-2 HC 11; GDCF-2 HC-11; chemokine (C-C motif) ligand2; Monocyte chemotactic protein1; Monocyte secretory protein JE; chemokine (C-C motif) ligand 2; Monocyte chemotactic protein 1; chemokine (C-C motif) ligand-2; Monocyte chemotactic protein-1; Monocyte chemoattractant protein1; Monocyte chemoattractant protein-1; Monocyte chemoattractant protein 1; Small inducible cytokine A2 precursor; Small inducible cytokine A 2 precursor; Monocyte chemotactic and activating factor; monocyte chemotactic protein 1, homologous to mouse Sig-je; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine A 2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)

FunctionThis gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0009618 response to pathogenic bacteria
GO:0050896 response to stimulus
GO:0006874 calcium ion homeostasis
GO:0004672 protein kinase activity
GO:0016020 membrane
GO:0019079 viral genome replication
GO:0005102 receptor binding
GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger
GO:0009887 organ morphogenesis
GO:0005615 extracellular space
GO:0007259 JAK-STAT cascade
GO:0007267 cell-cell signaling
GO:0006468 protein amino acid phosphorylation
GO:0007155 cell adhesion
GO:0006954 inflammatory response
GO:0006959 humoral immune response
GO:0006935 chemotaxis
GO:0006916 anti-apoptosis
GO:0008009 chemokine activity

Database cross references

STITCHCCL2

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
DARCin vivo
VCANin vitro
MMP1in vitro;in vivo
MMP8in vitro;in vivo
MMP3in vitro;in vivo
CCR10in vitro;in vivo
CCR1in vitro
CCR2in vitro;in vivo
CCR5in vivo
CCRL1in vitro
CCBP2in vivo
CCL2in vitro

Pathway (NetPath)PubMedRegulationExperiment
B Cell Receptor11898398 UpregulationMicroarray
IL-116264101,16447230,16085045,15464974 ,15336943 UpregulationMicroarray,Non-Microarray
IL-310641591,10704248 UpregulationNon-Microarray
IL-416220538 DownregulationMicroarray
IL-512600815 UpregulationMicroarray
Kit Receptor9373254,11378326 UpregulationNon-Microarray
TGF-beta Receptor14732924 DownregulationMicroarray
TNF-alpha15280531,14641910,12673210,12877984 UpregulationMicroarray,Non-Microarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

Pathway (CGAP/BioCarta)[Pertussis toxin-insensitive CCR5 Signaling in Macrophage ] [Low-density lipoprotein (LDL) pathway during atherogenesis ] [Msp/Ron Receptor Signaling Pathway ]


© 2008 National Taiwan Univerisity, Taipei, Taiwan