IDSwiss AccGene NameAliasDescription
5879P63000RAC1MIG5; TC-25; p21-Rac1; MGC111543ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
[more aliases]
FunctionThe protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.


Gene OntologyGO:0030041 actin filament polymerization
GO:0005515 protein binding
GO:0031529 ruffle organization and biogenesis
GO:0003924 GTPase activity
GO:0015031 protein transport
GO:0000166 nucleotide binding
GO:0005525 GTP binding
GO:0048261 negative regulation of receptor mediated endocytosis
GO:0030032 lamellipodium biogenesis
GO:0005622 intracellular
GO:0035025 positive regulation of Rho protein signal transduction
GO:0007264 small GTPase mediated signal transduction

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
STAT3in vivo;yeast 2-hybrid
ACTBin vitro;in vivo
ACTA1in vivo
DOCK1in vitro;in vivo
CHN1in vitro
AKT1in vitro;in vivo
NOS2Ain vitro;yeast 2-hybrid
EIF2AK2in vitro
PIK3R1in vitro
PRKCAin vivo
FLNAin vivo
TUBA4Ain vivo
PRKCIin vivo
MAP3K11in vitro
OPHN1in vitro
WASin vivo
CYBAin vitro
NCF2in vitro;in vivo;yeast 2-hybrid
NCK1in vivo
STAT1in vivo
IFNGR1in vivo
PLXNB1in vitro;in vivo
TIAM1in vitro;in vivo
VAV1in vivo
VAV2in vivo
KTN1yeast 2-hybrid
STAU1in vitro
CAV1in vivo
METAP2in vitro
TRIOin vitro;in vivo
ARHGDIAin vitro;in vivo;yeast 2-hybrid
RAC1in vitro;in vivo
DIAPH1in vitro;in vivo
PLD1in vivo
PAK1in vitro;in vivo
IL1RAPin vivo
ARHGDIBin vivo
IQGAP1in vitro;in vivo
NCKAP1in vitro;in vivo
PAK2in vitro
WASF1in vivo
BAIAP2in vitro;in vivo
VAV3in vitro
TNFRSF12Ain vivo
CYFIP1in vitro;in vivo
FHOD1in vitro;in vivo
PARD6Ain vitro;in vivo;yeast 2-hybrid
PAK7in vitro;in vivo
ARHGAP15in vitro
FMNL1in vitro;in vivo
ARFIP2in vitro;yeast 2-hybrid
RALBP1in vitro;yeast 2-hybrid
DOCK2in vitro
IQGAP2in vitro;in vivo
ICMTin vivo
TBC1D3in vivo
PARD6Gin vitro
RPS6KB1in vitro
SH3BP1in vitro
SYNJ2in vitro;in vivo;yeast 2-hybrid
ARHGEF2in vitro;in vivo
DEF6in vitro
DOCK8yeast 2-hybrid
PTPLAD1in vivo
RAP1GDS1yeast 2-hybrid
CDC42BPGin vitro
-in vitro
MCF2Lin vivo
CDC42SE1in vivo;yeast 2-hybrid
CDC42SE2yeast 2-hybrid
NOXA1in vitro;yeast 2-hybrid
RCC2in vitro;yeast 2-hybrid
PARD6Bin vitro;yeast 2-hybrid
OCRLin vitro
PLEKHG2in vitro
RASGRF1in vitro;in vivo
PIP5K2Ain vitro;in vivo
CASP3in vitro
DVL1in vivo
CASP7in vitro
DVL2in vivo
MAP3K4in vitro
TLR2in vivo
ARHGEF7in vitro
ARHGDIGin vitro;in vivo
CYBBin vivo
PARK2yeast 2-hybrid

Interacting Partners (NetPath)PAK1 [14579272 ] VAV1 [10727406 ] MEKK1 [9305638 ] MEKK4 [9305638 ] STAT3 [11021801 ]

Interacting Partner (IntAct)Interaction typeDetection method
PAK1 direct interaction fret
PARD6B physical interaction two hybrid, pull down, coip
ARFIP2 physical interaction, direct interaction two hybrid, pull down, beta galactosidase, x-ray
PARD6A physical interaction two hybrid, pull down
PARD6G physical interaction two hybrid, pull down
DOCK2 physical interaction pull down
PRKCI physical interaction two hybrid, pull down, coip
ELMO1 physical interaction pull down
STAU physical interaction, colocalization tap, imaging techniques
ARHGDIA direct interaction x-ray
NCF2 physical interaction, direct interaction itc, x-ray
MTNR1A physical interaction tap
PAK1 physical interaction pull down
PARK2 physical interaction two hybrid pooling
DOCK1 physical interaction pull down, anti tag coip

Pathway (NetPath)PubMedRegulationExperiment
T Cell Receptor11390484 DownregulationMicroarray

Pathway (KEGG)[MAPK signaling pathway] [Wnt signaling pathway] [Axon guidance] [VEGF signaling pathway] [Focal adhesion] [Adherens junction] [Toll-like receptor signaling pathway] [Natural killer cell mediated cytotoxicity]

Pathway (CGAP/BioCarta)[Y branching of actin filaments ] [Agrin in Postsynaptic Differentiation ] [Tumor Suppressor Arf Inhibits Ribosomal Biogenesis ] [Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling ] [BCR Signaling Pathway ] [Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration ] [Transcription factor CREB and its extracellular signals ] [Phospholipids as signalling intermediaries ] [fMLP induced chemokine gene expression in HMC-1 cells ] [Role of MAL in Rho-Mediated Activation of SRF ] [MAPKinase Signaling Pathway ] [Ras-Independent pathway in NK cell-mediated cytotoxicity ] [p38 MAPK Signaling Pathway ] [Phosphoinositides and their downstream targets. ] [Links between Pyk2 and Map Kinases ] [Rac 1 cell motility signaling pathway ] [Influence of Ras and Rho proteins on G1 to S Transition ] [Ras Signaling Pathway ] [How does salmonella hijack a cell ] [T Cell Receptor Signaling Pathway ] [uCalpain and friends in Cell spread ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan