IDSwiss AccGene NameAliasDescription
5604Q02750MAP2K1MEK1; MKK1; MAPKK1; PRKMK1mitogen-activated protein kinase kinase 1
[more aliases]
FunctionThe protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.


Gene OntologyGO:0005515 protein binding
GO:0004674 protein serine/threonine kinase activity
GO:0000166 nucleotide binding
GO:0006468 protein amino acid phosphorylation
GO:0005524 ATP binding
GO:0004672 protein kinase activity
GO:0006928 cell motility
GO:0006935 chemotaxis
GO:0004708 MAP kinase kinase activity
GO:0016740 transferase activity
GO:0004713 protein-tyrosine kinase activity
GO:0007165 signal transduction

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
EP300in vitro;in vivo
CDK5in vitro;in vivo
BRAFin vitro;in vivo
RAF1in vitro;in vivo
MAP2K1in vitro;in vivo
MAPK1in vitro;in vivo;yeast 2-hybrid
HRASin vivo
MYCin vitro
ARAFin vitro
GRB10in vitro;in vivo;yeast 2-hybrid
RPS6KA2in vitro
MAPK3in vitro;in vivo
TRAF3in vitro;in vivo
CASP9in vitro;in vivo
MAP3K4in vitro;in vivo
PAK1in vitro;in vivo
MAP2K1IP1in vitro;in vivo;yeast 2-hybrid
RPS6KA4in vitro;in vivo
CPNE1in vitro
CPNE4in vitro
PEBP1in vitro;in vivo
TRIB1in vivo
-in vitro;in vivo
MAPK8IP3in vitro
KSR2in vitro
PARVAin vivo
PLK3in vitro
PRKCZin vitro
PRKCIin vitro
ELK1in vitro
MAPK14in vitro;in vivo
TRAF6in vitro
EGFRin vitro;in vivo
KSR1in vivo

Interacting Partners (NetPath)MAPK1 [8670897 ]

Interacting Partner (IntAct)Interaction typeDetection method
TRIB1 physical interaction anti tag coip
TRIB3 physical interaction anti tag coip
HLA-B physical interaction anti bait coip

Pathway (NetPath)PubMedRegulationExperiment
TGF-beta Receptor15845540 DownregulationMicroarray
TNF-alpha14641910,12673210 UpregulationMicroarray

Pathway (KEGG)[MAPK signaling pathway] [Dorso-ventral axis formation] [VEGF signaling pathway] [Focal adhesion] [Gap junction] [Natural killer cell mediated cytotoxicity] [Fc epsilon RI signaling pathway]

Pathway (CGAP/BioCarta)[Anthrax Toxin Mechanism of Action ] [Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling ] [Role of ß-arrestins in the activation and targeting of MAP kinases ] [Roles of ß-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling ] [BCR Signaling Pathway ] [Bioactive Peptide Induced Signaling Pathway ] [CCR3 signaling in Eosinophils ] [Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway ] [Cadmium induces DNA synthesis and proliferation in macrophages ] [Ceramide Signaling Pathway ] [CXCR4 Signaling Pathway ] [Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia ] [EGF Signaling Pathway ] [Map Kinase Inactivation of SMRT Corepressor ] [EPO Signaling Pathway ] [Erk1/Erk2 Mapk Signaling pathway ] [Fc Epsilon Receptor I Signaling in Mast Cells ] [fMLP induced chemokine gene expression in HMC-1 cells ] [Growth Hormone Signaling Pathway ] [Inhibition of Cellular Proliferation by Gleevec ] [Signaling Pathway from G-Protein Families ] [Human Cytomegalovirus and Map Kinase Pathways ] [Role of ERBB2 in Signal Transduction and Oncology ] [IGF-1 Signaling Pathway ] [Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation ] [IL 2 signaling pathway ] [IL 3 signaling pathway ] [IL 6 signaling pathway ] [Insulin Signaling Pathway ] [Integrin Signaling Pathway ] [Keratinocyte Differentiation ] [Role of MAL in Rho-Mediated Activation of SRF ] [MAPKinase Signaling Pathway ] [Signaling of Hepatocyte Growth Factor Receptor ] [NFAT and Hypertrophy of the heart (Transcription in the broken heart) ] [Nerve growth factor pathway (NGF) ] [Ras-Independent pathway in NK cell-mediated cytotoxicity ] [PDGF Signaling Pathway ] [Links between Pyk2 and Map Kinases ] [Ras Signaling Pathway ] [Aspirin Blocks Signaling Pathway Involved in Platelet Activation ] [Sprouty regulation of tyrosine kinase signals ] [T Cell Receptor Signaling Pathway ] [TGF beta signaling pathway ] [TPO Signaling Pathway ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan