IDSwiss AccGene NameAliasDescription
5599P45983MAPK8JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2mitogen-activated protein kinase 8
[more aliases]
FunctionThe protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0006950 response to stress
GO:0005515 protein binding
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0006468 protein amino acid phosphorylation
GO:0004705 JUN kinase activity
GO:0006928 cell motility
GO:0016740 transferase activity
GO:0007165 signal transduction
GO:0007254 JNK cascade

Database cross references

STITCHMAPK8

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
STAT3in vitro;in vivo
CDKN1Ain vitro;in vivo
WWOXin vivo;yeast 2-hybrid
ATF2in vitro;in vivo
GSTP1in vitro;in vivo
NR3C1in vitro;in vivo
HSF1in vitro;in vivo
IRS1in vitro;in vivo;yeast 2-hybrid
KRT8in vitro;in vivo
CRKin vitro;in vivo
BCL2in vivo
RELin vivo;yeast 2-hybrid
XRCC6in vitro;in vivo
JUNBin vitro;in vivo
JUNDin vitro
PAX2in vitro;in vivo
MAP1Bin vivo
PIK3R1in vivo
TP53in vitro;in vivo
HRASin vivo
MYCin vitro;in vivo
PRKDCin vitro;in vivo
MAPK14in vivo
MAPK3in vivo
JUNin vivo
MAPK1in vivo
ELK3in vitro
MAP2K4in vitro
PPARGin vitro;in vivo
PXNin vitro;in vivo
MAP3K7in vitro;in vivo
TNFSF11in vivo
SNCGin vivo
MAP2K7in vitro;in vivo
SMAD3in vitro;in vivo
IKBKAPin vitro;in vivo
BCL2L11in vitro;in vivo
MAPK8IP1in vitro;in vivo
PRKD1in vivo
DUSP1yeast 2-hybrid
SPIBin vitro
EEF2Kin vitro
IL27RAin vivo
DUSP16in vivo
MAPK8IP2in vitro;in vivo
MAP3K2in vitro;in vivo
SPAG9in vitro;in vivo
MAPK8IP3in vitro;in vivo;yeast 2-hybrid
SH3BP5in vitro
DUSP10in vitro;yeast 2-hybrid
DUSP22in vivo
-in vitro;in vivo
MAPKBP1in vitro;in vivo
DUSP4in vivo
DUSP7in vivo
BMFin vitro
COPS2in vivo
BCL2L1in vitro
IRAK1in vivo
ELK1in vitro
SMAD2in vitro;in vivo
BADin vitro
HSF4in vitro
RETin vitro
C14orf100in vitro;in vivo
CDC42in vivo
ITSN1in vivo
YWHAZin vivo

Interacting Partner (IntAct)Interaction typeDetection method
MAP2K4 direct interaction pull down
ATF2 phosphorylation protein kinase assay
- physical interaction pull down
MAP2K4 physical interaction pull down
JUN phosphorylation protein kinase assay
JUN phosphorylation protein kinase assay

Pathway (NetPath)PubMedRegulationExperiment
IL-512600815 UpregulationMicroarray
TGF-beta Receptor12619158 DownregulationMicroarray
TNF-alpha12877984 UpregulationMicroarray

Pathway (KEGG)[MAPK signaling pathway] [Wnt signaling pathway] [Focal adhesion] [Toll-like receptor signaling pathway] [Fc epsilon RI signaling pathway] [Insulin signaling pathway] [GnRH signaling pathway]

Pathway (CGAP/BioCarta)[The 4-1BB-dependent immune response ] [Agrin in Postsynaptic Differentiation ] [Oxidative Stress Induced Gene Expression Via Nrf2 ] [Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling ] [ATM Signaling Pathway ] [BCR Signaling Pathway ] [Bioactive Peptide Induced Signaling Pathway ] [Pertussis toxin-insensitive CCR5 Signaling in Macrophage ] [Ceramide Signaling Pathway ] [Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases ] [EGF Signaling Pathway ] [EPO Signaling Pathway ] [FAS signaling pathway ( CD95 ) ] [Fc Epsilon Receptor I Signaling in Mast Cells ] [Inhibition of Cellular Proliferation by Gleevec ] [HIV-I Nef: negative effector of Fas and TNF ] [IGF-1 Signaling Pathway ] [IL12 and Stat4 Dependent Signaling Pathway in Th1 Development ] [Signal transduction through IL1R ] [IL 2 signaling pathway ] [Insulin Signaling Pathway ] [Integrin Signaling Pathway ] [Keratinocyte Differentiation ] [Role of MAL in Rho-Mediated Activation of SRF ] [MAPKinase Signaling Pathway ] [Signaling of Hepatocyte Growth Factor Receptor ] [NFAT and Hypertrophy of the heart (Transcription in the broken heart) ] [Nerve growth factor pathway (NGF) ] [Hypoxia and p53 in the Cardiovascular system ] [PDGF Signaling Pathway ] [Links between Pyk2 and Map Kinases ] [Bone Remodelling ] [TNF/Stress Related Signaling ] [TACI and BCMA stimulation of B cell immune responses. ] [T Cell Receptor Signaling Pathway ] [TNFR1 Signaling Pathway ] [Toll-Like Receptor Pathway ]


© 2008 National Taiwan Univerisity, Taipei, Taiwan