IDSwiss AccGene NameAliasDescription
5594P28482MAPK1ERK; p38; p40; p41; ERK2; ERT1; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapkmitogen-activated protein kinase 1
[more aliases]
FunctionThe protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.


Gene OntologyGO:0006950 response to stress
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0007049 cell cycle
GO:0000166 nucleotide binding
GO:0006468 protein amino acid phosphorylation
GO:0005524 ATP binding
GO:0007268 synaptic transmission
GO:0006935 chemotaxis
GO:0016740 transferase activity
GO:0007165 signal transduction
GO:0006917 induction of apoptosis

Database cross references



Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
STAT3in vitro;in vivo
ARRB1in vitro
GRB2in vivo
CD19in vitro
IFNAR1in vitro;in vivo
GAB1in vitro
GJA1in vitro;in vivo
EPORin vivo
ESR1in vitro;in vivo
NR3C1in vitro;in vivo
NR4A1in vitro;in vivo
HSP90AA1in vivo
TCF3in vivo
KRT8in vitro;in vivo
ETS1in vitro
MBPin vitro
PLATin vitro
FOSin vitro;in vivo
VAV1in vivo
BCL2in vivo
LIFRin vivo
SNCAin vivo
LIPEin vitro
MAP2K1in vitro;in vivo;yeast 2-hybrid
LCKin vitro;in vivo
PTPN5in vitro;in vivo
PTPN1in vitro
PTPN7in vitro;in vivo
PPARAin vitro
MAPK1in vitro
PRKCEin vivo
RB1in vitro
RXRAin vitro;in vivo
SREBF1in vitro
NR5A1in vivo
SP1in vitro;in vivo
CEBPBin vitro
MYBin vitro;in vivo
ZFP36in vitro;in vivo
TP53in vitro;in vivo
NTRK3in vitro
RPS6KA3in vivo
ELK1in vitro
DUSP3in vitro;in vivo
MAPK14in vitro
SREBF2in vitro
SHC1in vitro;in vivo
TITF1in vitro;in vivo
UBTFin vitro;in vivo
DUSP1in vitro;in vivo;yeast 2-hybrid
SCNN1Gin vitro
SMAD4in vitro;in vivo
MAP2K2in vitro;in vivo;yeast 2-hybrid
C1QBPin vitro;in vivo
PPARGin vitro;in vivo
STAT5Ain vitro;in vivo
RPS6KA1in vitro;in vivo
RPS6KA2in vitro;in vivo
GMFBin vivo
METAP2in vitro
NCOA3in vitro
EIF4EBP1in vitro;in vivo
CASP9in vitro;in vivo
KHDRBS1in vitro
PXNin vitro
PTPRHin vivo
TNFSF11in vitro;in vivo
NCOA1in vitro;in vivo
DUSP4in vivo
DUSP7in vivo
PTPRRin vitro;in vivo;yeast 2-hybrid
IER3in vitro;in vivo
SNCGin vivo
DUSP5in vitro;in vivo;yeast 2-hybrid
MAP2K1IP1in vitro
KLF11in vitro;in vivo
TNFRSF25in vitro;in vivo
IQGAP1in vitro;in vivo
PEA15in vitro;in vivo;yeast 2-hybrid
RPS6KA4in vitro;in vivo
NEK2in vitro;in vivo;yeast 2-hybrid
STAT5Bin vitro
DYRK1Bin vitro
MKNK2in vitro;yeast 2-hybrid
RGS19in vitro;in vivo
HDAC4in vitro
GAB2in vitro;in vivo
FRS3in vitro;in vivo;yeast 2-hybrid
EDD1in vitro;in vivo
CADin vitro
PEBP1in vitro;in vivo
GORASP2in vitro
TPRin vitro;in vivo
FHL3in vitro
TNIP1in vitro;in vivo;yeast 2-hybrid
TOB1in vitro;in vivo;yeast 2-hybrid
MAPKAPK5in vitro;in vivo
MKNK1in vitro;yeast 2-hybrid
DUSP16in vivo
ERFin vitro;in vivo
CALCOCO1in vitro
KSR2in vitro
MAFAin vitro;in vivo
NDE1in vitro
GABRR1in vitro
SORBS3in vivo
RPS6KB1in vivo
PRKCDin vivo
MAPK8in vivo
PPP1R9Bin vitro;in vivo
MCL1in vitro
RAF1in vitro;in vivo
PRKCZin vivo
THin vivo
ARRB2in vitro
CDX2in vitro
SLC9A1in vitro
GRB10in vitro;in vivo
DUSP2in vitro
PLK3in vitro
TSC2in vitro;in vivo
SMAD3in vitro;in vivo
SMAD2in vitro
SMAD1in vitro;in vivo
DUSP6in vitro;in vivo
PAK1in vitro;in vivo
IRS1in vitro
TNFRSF1Ain vitro
PTPREin vitro
NEFHin vitro;in vivo
SOS1in vitro;in vivo
MITFin vitro;in vivo
NGFRin vitro;in vivo
BRAFin vitro
JUNDin vitro;in vivo
GATA1in vitro
ARin vitro;in vivo
CAV1in vivo
TGIF1in vitro;in vivo
SH2D3Cin vivo
PAK2in vitro
PLCB1in vitro
FRS2in vitro
FCGR2Bin vivo
PPP2CAin vitro
PPP1CAin vitro
CMTM3in vivo
DAPK1in vitro;yeast 2-hybrid
BCL6in vitro
EGFRin vitro;in vivo
HSF4in vivo
GATA2in vitro
CEP55in vitro
RETin vitro
DUSP9yeast 2-hybrid

Interacting Partners (NetPath)MAP2K1 [8670897 ] GAB2 [12008033 ] GAB1 [12008033 ] FCGR2B [15081531 ] CMTM3 [15087455 ] LCK [7499846 ] VAV1 [9013873 ] STAT3 [11780390 ]

Interacting Partner (IntAct)Interaction typeDetection method
DUSP1 physical interaction, phosphorylation pull down, protein kinase assay
TNIK physical interaction anti bait coip
HLA-B physical interaction anti bait coip
ELK1 phosphorylation protein kinase assay
PACSIN3 physical interaction anti bait coip

Pathway (NetPath)PubMedRegulationExperiment
IL-212536241 DownregulationNon-Microarray

Pathway (KEGG)[MAPK signaling pathway] [mTOR signaling pathway] [Dorso-ventral axis formation] [TGF-beta signaling pathway] [Axon guidance] [VEGF signaling pathway] [Focal adhesion] [Adherens junction] [Gap junction]

Pathway (CGAP/BioCarta)[Agrin in Postsynaptic Differentiation ] [Oxidative Stress Induced Gene Expression Via Nrf2 ] [Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling ] [Regulation of BAD phosphorylation ] [Role of ß-arrestins in the activation and targeting of MAP kinases ] [Roles of ß-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling ] [Bioactive Peptide Induced Signaling Pathway ] [CCR3 signaling in Eosinophils ] [Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway ] [Cadmium induces DNA synthesis and proliferation in macrophages ] [Ceramide Signaling Pathway ] [Transcription factor CREB and its extracellular signals ] [CXCR4 Signaling Pathway ] [Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia ] [Phospholipids as signalling intermediaries ] [Regulation of eIF4e and p70 S6 Kinase ] [Role of Erk5 in Neuronal Survival ] [Erk1/Erk2 Mapk Signaling pathway ] [Fc Epsilon Receptor I Signaling in Mast Cells ] [fMLP induced chemokine gene expression in HMC-1 cells ] [Human Cytomegalovirus and Map Kinase Pathways ] [Role of ERBB2 in Signal Transduction and Oncology ] [Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation ] [Integrin Signaling Pathway ] [Keratinocyte Differentiation ] [Role of MAL in Rho-Mediated Activation of SRF ] [MAPKinase Signaling Pathway ] [Signaling of Hepatocyte Growth Factor Receptor ] [NFAT and Hypertrophy of the heart (Transcription in the broken heart) ] [Pelp1 Modulation of Estrogen Receptor Activity ] [PTEN dependent cell cycle arrest and apoptosis ] [Links between Pyk2 and Map Kinases ] [Influence of Ras and Rho proteins on G1 to S Transition ] [Regulation of Splicing through Sam68 ] [Aspirin Blocks Signaling Pathway Involved in Platelet Activation ] [Sprouty regulation of tyrosine kinase signals ] [Trefoil Factors Initiate Mucosal Healing ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan