IDSwiss AccGene NameAliasDescription
3630P01308INSNo gene aliasesinsulin
[more aliases]
FunctionAfter removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified.


Gene OntologyGO:0042177 negative regulation of protein catabolism
GO:0007166 cell surface receptor linked signal transduction
GO:0005520 insulin-like growth factor binding
GO:0045429 positive regulation of nitric oxide biosynthesis
GO:0050715 positive regulation of cytokine secretion
GO:0005158 insulin receptor binding
GO:0045908 negative regulation of vasodilation
GO:0045909 positive regulation of vasodilation
GO:0046631 alpha-beta T cell activation
GO:0006006 glucose metabolism
GO:0005975 carbohydrate metabolism
GO:0005515 protein binding
GO:0007582 physiological process
GO:0007267 cell-cell signaling
GO:0015758 glucose transport
GO:0050708 regulation of protein secretion
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0005576 extracellular region
GO:0006091 generation of precursor metabolites and energy
GO:0008219 cell death
GO:0006953 acute-phase response
GO:0005179 hormone activity

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
CTSBin vitro
CTSDin vitro;in vivo
CTSEin vitro
CPEin vivo
IDEin vitro
INSRin vivo
IGF1Rin vivo
INSin vivo
LRP2in vitro
IGFBP7in vitro
HLA-DQB1in vitro
SYTL4in vitro
HLA-DQA2in vitro
TXNL5in vitro
NOVin vitro
GCKin vitro
RB1in vitro;in vivo

Pathway (KEGG)[Regulation of autophagy] [mTOR signaling pathway] [Regulation of actin cytoskeleton] [Insulin signaling pathway] [Type II diabetes mellitus] [Type I diabetes mellitus] [Maturity onset diabetes of the young]

Pathway (CGAP/BioCarta)[Growth Hormone Signaling Pathway ] [Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) ] [Insulin Signaling Pathway ] [Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan