IDSwiss AccGene NameAliasDescription
3627P02778CXCL10IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10chemokine (C-X-C motif) ligand 10
[more aliases]
FunctionThis gene encodes the interferon (gamma)-induced protein of 10kDa, a chemokine of the CXC subfamily that is one of the ligands for the receptor CXCR3. The binding of this protein to CXCR3 causes pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression.


Gene OntologyGO:0007517 muscle development
GO:0007166 cell surface receptor linked signal transduction
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0050896 response to stimulus
GO:0008015 circulation
GO:0005625 soluble fraction
GO:0006954 inflammatory response
GO:0006928 cell motility
GO:0005102 receptor binding
GO:0008009 chemokine activity
GO:0006935 chemotaxis
GO:0005615 extracellular space

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
VCANin vitro
DPP4in vitro
CXCR3in vitro;in vivo
CCR3in vitro
IGFBP7in vivo
CXCL10in vitro

Pathway (NetPath)PubMedRegulationExperiment
B Cell Receptor11898398 UpregulationMicroarray
IL-711418668 DownregulationMicroarray
EGFR116266819 DownregulationMicroarray
TNF-alpha12212969,14641910 UpregulationMicroarray,Non-Microarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction] [Toll-like receptor signaling pathway]

© 2008 National Taiwan Univerisity, Taipei, Taiwan