IDSwiss AccGene NameAliasDescription
3606Q14116IL18IGIF; IL-18; IL-1g; IL1F4; MGC12320interleukin 18 (interferon-gamma-inducing factor)

Other aliasesIGIF; IL18; IL-1g; IL1F4; IL-18; IL 18; IL1F 4; IL-1 c; IL-1 g; IL1F-4; IL 1 F-4; IL 1 F 4; MGC12320; MGC-12320; IL-1gamma; MGC 12320; IL-1 gamma; Iboctadekin; interleukin18; interleukin-1g; interleukin 18; interleukin-18; interleukin-1 g; Interleukin-1 c; interleukin 1 F-4; interleukin 1 F 4; Interleukin-1gamma; Interleukin-1 gamma; Interleukin-18 precursor; IFN-gamma-inducing factor; Interferon-gamma-inducing factor; IL 18 interferon-gamma-inducing factor; IL 18 (interferongamma-inducing factor); IL 18 (interferon-gammainducing factor); interleukin 18 IFN-gamma-inducing factor; IL 18 (interferon-gamma-inducing factor); interleukin 18 (IFN-gammainducing factor); interleukin 18 (IFN-gamma-inducing factor); interleukin 18 interferon-gamma-inducing factor; interleukin 18 (interferongamma-inducing factor); interleukin 18 (interferon-gammainducing factor); interleukin 18 (interferon-gamma-inducing factor)

FunctionThe protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.


Gene OntologyGO:0042092 T-helper 2 type immune response
GO:0042104 positive regulation of activated T cell proliferation
GO:0001525 angiogenesis
GO:0008625 induction of apoptosis via death domain receptors
GO:0005615 extracellular space
GO:0042095 interferon-gamma biosynthesis
GO:0006955 immune response
GO:0005125 cytokine activity
GO:0007267 cell-cell signaling
GO:0005149 interleukin-1 receptor binding
GO:0042094 interleukin-2 biosynthesis
GO:0030155 regulation of cell adhesion
GO:0042253 granulocyte macrophage colony-stimulating factor biosynthesis
GO:0004871 signal transducer activity
GO:0042033 chemokine biosynthesis
GO:0005576 extracellular region
GO:0030431 sleep
GO:0042231 interleukin-13 biosynthesis

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
CASP1in vitro;in vivo
IL18BPin vitro;in vivo
IL18R1in vitro;in vivo
IL18RAPin vivo
IL1RL2in vitro;in vivo
CASP3in vitro
CASP4in vivo

Pathway (NetPath)PubMedRegulationExperiment
IL-415869882 DownregulationNon-Microarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction]

Pathway (CGAP/BioCarta)[Cytokine Network ] [IL12 and Stat4 Dependent Signaling Pathway in Th1 Development ] [IL 18 Signaling Pathway ] [Ras-Independent pathway in NK cell-mediated cytotoxicity ] [Th1/Th2 Differentiation ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan