IDSwiss AccGene NameAliasDescription
3586P22301IL10CSIF; TGIF; IL-10; IL10A; MGC126450; MGC126451interleukin 10
[more aliases]
FunctionThe protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0042092 T-helper 2 type immune response
GO:0045019 negative regulation of nitric oxide biosynthesis
GO:0045347 negative regulation of MHC class II biosynthesis
GO:0045077 negative regulation of interferon-gamma biosynthesis
GO:0030183 B cell differentiation
GO:0030097 hemopoiesis
GO:0005615 extracellular space
GO:0045355 negative regulation of interferon-alpha biosynthesis
GO:0007253 cytoplasmic sequestering of NF-kappaB
GO:0005141 interleukin-10 receptor binding
GO:0005125 cytokine activity
GO:0007267 cell-cell signaling
GO:0030595 immune cell chemotaxis
GO:0042100 B cell proliferation
GO:0045191 regulation of isotype switching
GO:0005576 extracellular region
GO:0006916 anti-apoptosis
GO:0042130 negative regulation of T cell proliferation

Database cross references

PharmGKBPA29778

STITCHIL10

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
A2Min vitro
IL10RBin vitro;in vivo
IL10RAin vitro;in vivo
IL10in vitro

Interacting Partner (IntAct)Interaction typeDetection method
IL10RA direct interaction x-ray

Pathway (NetPath)PubMedRegulationExperiment
T Cell Receptor15950730 UpregulationNon-Microarray
B Cell Receptor12393419 UpregulationNon-Microarray
IL-212055219 UpregulationMicroarray,Non-Microarray
IL-49886391,15869882 UpregulationNon-Microarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction] [Jak-STAT signaling pathway] [T cell receptor signaling pathway]

Pathway (CGAP/BioCarta)[Antigen Dependent B Cell Activation ] [Cytokine Network ] [Dendritic cells in regulating TH1 and TH2 Development ] [IL-10 Anti-inflammatory Signaling Pathway ] [Cytokines and Inflammatory Response ]


© 2008 National Taiwan Univerisity, Taipei, Taiwan