IDSwiss AccGene NameAliasDescription
3569P05231IL6HSF; BSF2; IL-6; IFNB2interleukin 6 (interferon, beta 2)
[more aliases]
FunctionInformation is not available.


Gene OntologyGO:0007166 cell surface receptor linked signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0005125 cytokine activity
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0001781 neutrophil apoptosis
GO:0006959 humoral immune response
GO:0045079 negative regulation of chemokine biosynthesis
GO:0005615 extracellular space
GO:0006953 acute-phase response
GO:0005138 interleukin-6 receptor binding

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
IL6Rin vitro;in vivo
PTHLHin vitro
IL6STin vivo
SH3GL2yeast 2-hybrid
ZBTB16yeast 2-hybrid

Interacting Partners (NetPath)IL6R [14557255 ]

Interacting Partner (IntAct)Interaction typeDetection method
ZBTB16 physical interaction two hybrid pooling
IL6R physical interaction x-ray
SH3GL2 physical interaction two hybrid pooling
IL6ST physical interaction x-ray

Pathway (NetPath)PubMedRegulationExperiment
Alpha6 Beta4 Integrin14579272 UpregulationNon-Microarray
T Cell Receptor15950730,9712721 UpregulationMicroarray,Non-Microarray
IL-116264101,16447230,15950496,15525570,15464974 UpregulationMicroarray,Non-Microarray
IL-28038234 UpregulationNon-Microarray
IL-415869882 DownregulationNon-Microarray
Androgen Receptor8798655 DownregulationNon-Microarray
Kit Receptor11032806 UpregulationNon-Microarray
TGF-beta Receptor15582131,10709997,14726474,15571627 UpregulationMicroarray,Non-Microarray
TNF-alpha15454581 DownregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction] [Toll-like receptor signaling pathway] [Jak-STAT signaling pathway] [Hematopoietic cell lineage] [Prion disease]

Pathway (CGAP/BioCarta)[Cytokine Network ] [Erythrocyte Differentiation Pathway ] [Role of ERBB2 in Signal Transduction and Oncology ] [IL-10 Anti-inflammatory Signaling Pathway ] [IL 17 Signaling Pathway ] [Signal transduction through IL1R ] [IL 5 Signaling Pathway ] [IL 6 signaling pathway ] [Cytokines and Inflammatory Response ] [Cells and Molecules involved in local acute inflammatory response ] [Low-density lipoprotein (LDL) pathway during atherogenesis ] [Regulation of hematopoiesis by cytokines ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan