IDSwiss AccGene NameAliasDescription
3567P05113IL5EDF; TRF; IL-5interleukin 5 (colony-stimulating factor, eosinophil)

Other aliasesIL5; EDF; TRF; IL 5; IL-5; interleukin5; interleukin-5; interleukin 5; T-cell replacing factor; Interleukin-5 precursor; B cell differentiation factor I; Eosinophil differentiation factor; IL 5 colony-stimulating factor, eosinophil; IL 5 (colony-stimulating factor, eosinophil); interleukin 5 colony-stimulating factor, eosinophil; interleukin 5 (colony-stimulating factor, eosinophil)

FunctionThe protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.


Gene OntologyGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0006954 inflammatory response
GO:0005125 cytokine activity
GO:0005137 interleukin-5 receptor binding
GO:0005615 extracellular space

Database cross references


Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
IL5RAin vitro;in vivo
IL5in vitro

Interacting Partners (NetPath)IL5 [7534492 ] IL5RA [1732409,8454628 ] CSF2RB [12202242 ]

Pathway (NetPath)PubMedRegulationExperiment
T Cell Receptor15950730,11390484 UpregulationNon-Microarray
IL-215735688 UpregulationMicroarray,Non-Microarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction] [Jak-STAT signaling pathway] [Hematopoietic cell lineage] [T cell receptor signaling pathway] [Fc epsilon RI signaling pathway]

Pathway (CGAP/BioCarta)[Cytokine Network ] [Dendritic cells in regulating TH1 and TH2 Development ] [The Role of Eosinophils in the Chemokine Network of Allergy ] [GATA3 participate in activating the Th2 cytokine genes expression ] [IL 5 Signaling Pathway ] [Cytokines and Inflammatory Response ] [Selective expression of chemokine receptors during T-cell polarization ] [Regulation of hematopoiesis by cytokines ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan