IDSwiss AccGene NameAliasDescription
3558P60568IL2IL-2; TCGF; lymphokineinterleukin 2
[more aliases]
FunctionThe protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0030101 natural killer cell activation
GO:0019209 kinase activator activity
GO:0005125 cytokine activity
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0030307 positive regulation of cell growth
GO:0007155 cell adhesion
GO:0030217 T cell differentiation
GO:0019735 antimicrobial humoral response (sensu Vertebrata)
GO:0006916 anti-apoptosis
GO:0005134 interleukin-2 receptor binding
GO:0006955 immune response
GO:0005615 extracellular space

Database cross references

STITCHIL2

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
IL2RBin vivo
IFNA1in vitro
IL2in vitro
FOXK2in vitro
IL2RAin vivo
CD53in vivo
NGFRin vitro
IL2RGin vivo
SHC1in vitro

Interacting Partners (NetPath)IL2RA [3116143,8468475,8894436,8976555,11851401,16477002,] IL2RB [2467293,3116143,2201821,8468475,16477002,16293754,]

Pathway (NetPath)PubMedRegulationExperiment
T Cell Receptor15950730,12165505,12065418,11390484 UpregulationMicroarray,Non-Microarray
IL-79326236 UpregulationNon-Microarray
TNF-alpha12754109 UpregulationMicroarray

Pathway (KEGG)[Cytokine-cytokine receptor interaction] [Jak-STAT signaling pathway] [T cell receptor signaling pathway] [Type I diabetes mellitus]

Pathway (CGAP/BioCarta)[The 4-1BB-dependent immune response ] [Antigen Dependent B Cell Activation ] [The Co-Stimulatory Signal During T-cell Activation ] [Cytokine Network ] [IL 18 Signaling Pathway ] [IL 2 signaling pathway ] [Cytokines and Inflammatory Response ] [Selective expression of chemokine receptors during T-cell polarization ] [OX40 Signaling Pathway ] [Regulation of hematopoiesis by cytokines ] [Th1/Th2 Differentiation ] [Role of Tob in T-cell activation ]


© 2008 National Taiwan Univerisity, Taipei, Taiwan